Holds true for other substances as well. My brother absolutely loves weed and finds it relaxing but I cannot use even a small amount without crippling levels of anxiety. Meanwhile anything that works on GABA (alcohol included) completely removes anxiety for me in a way that's so enjoyable I have to be careful with the whole class of substances. Because of a genetic quirk modafinil has little to no effect if I take it but I use prescribed amphetamines 3-5 days a week. Human bodies are complicated!
I was shocked, about 15 years ago when some Italian friends (who were very drug familiar) said how much they liked that they could buy Benadryl (diphenhydramine) w/o a prescription here in the USA.
I was like "????*" this is not a party drug.
(note: there are folks who use it in massive overdoses as an ACh deliriant [1] but that's not my cup of tea)