Like for instance... Apple Integer BASIC was a GREAT technology if all you had was an Apple ][ with 16k of RAM and were writing programs that interacted with a single user via the keyboard and monitor. If you have an array of hosts serving a web app and it's persistence tier up in someone else's datacenter, Apple Integer BASIC would not be my first choice.
But HTMX with it's conflation of presentation and business logic would also not be my first choice.