I've done professional typesetting and cataloging with QuarkXPress and InDesign both and it was extremely fast, that's for professional high quality publishing. .doc and .md is fine for information first publishing.
Latex is not simple and is in my opinion just a big nerd snipe, its the intrusive thought of layout software, for humanities sake we'd be better off with simpler tools like markdown + math notation and if latex had been never invented.