I have trouble landing interviews at FAANGs with 15+ years as an eng. and successful acquisitions as a founder - but those don't mean anything if you don't have direct knowledge of certain tools to handle scale or experience guiding projects across departments, etc. Which makes sense for any role past junior, since part of the value you bring is experience and only some of your experience is directly applicable. Vaguely being competent doesn't really move the needle.
On the other hand, I've heard stories of people getting hired from a FAANG going to a startup and not able to shift their mindset to a "make it work" approach, so the challenge goes both ways.