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Rome is not a runtime and picking one depends on your use case and personal preference about certain features.

Rome is not a runtime, it’s a toolchain.

Is Rome still being actively developed? Haven't heard much about it in years.

If you want to experiment with something new and fun pick bun or deno.

If you're looking to currently build a larger scale project with a few people that supports a lot of users, it's safer to go with nodejs/typescript.