Research reveals the scale of disorder underpinning motor neuron disease

If true it would be fantastic, here are a few thoughts:

- It's not just that proteins like TDP-43 are mislocalized, it's also that they are misfolded and form aggregates in ALS.

- ALS cells have been scrutinized since two decades, how this was not observed?

- If there is such a scale of disorder in ALS patients, won't they would die in days instead of months?

- An excerpt form Wikipedia: "Mutations in VCP are an example of pleiotropy, where mutations in the same gene give rise to different phenotypes. The term multisystem proteinopathy (MSP) has been coined to describe this particular form of pleiotropy."

Get AGI on this stuff already