I'm not sure about negative mass, but negative energy density can be achieved with the Casimir effect.
https://en.wikipedia.org/wiki/Laser
https://en.wikipedia.org/wiki/Population_inversion
https://en.wikipedia.org/wiki/Negative_temperature#Lasers
(Negative thermodynamic temperature has very unintuitive effects in general, so maybe read all of the last article to get an idea)