why do you think "This difference gets lost in the THD already at the DAC "? Do you have numbers to back it up? What's the noise floor of DAC? What's the noise floor of an output stage? Do you have the number?
I am not saying that there aren't any DACs on the planet that can't handle five millionths of a volt, but I am saying that five millionths of a volt isn't surviving through the particular DACs and the rest of the electronics used in your PC/living room hi-fi audio equipment.