From my experience:
1. there is a humongous difference between remote work in (roughly) the same time zone and fully distributed work across the globe
2. having non EU employees as a EU company without having a daughter company in the country the employees are in, without them moving to the EU during the employment, without them being self employees/free lancers it a complete nightmare to get legally right. Worse a nightmare which not only changes between any country pairing (different EU countries have different employment laws) in case of the US might even change depending on the US state.... AFIK all companies either only hire freelancers, do have non-EU daughter companies, do hire through a proxy firm (there are firms exactly for this, but there are their own legal mess), or do it not fully legally right. At the same time having a US daughter company also comes as a cost (many a way more complex legal structure). And all of this method still have high book keeping/complexity/fee cost.
3. legal hassles of data protection and having e.g. sys admin outside of the EU (and in case of dev ops that can easily extend to large parts of the team depending on how it was implemented).
So from a business POV it can make a lot of sense, especially if they plane to mostly milk Evernote.
Through without question it has a very high potential for disruption of Evernote development and operation.
> approx €50k/year, though the cost for the employer is higher
yes WAY higher, and you also pay a good amount of the 50k in taxes but together this then covers pension, unemployment and health insurance around 20 payed vacation days and additional payed holiday days, various child benefits if you have one depending on country and in most cases reasonable employee and employer rights and protections trying to avoid power abuse in both directions (through mainly protecting the employed person).