I'd like to see a fork of SQLite that "supports the PostgreSQL wire protocol and the majority of PostgreSQL syntax" (to quote another popular db).
https://blog.turso.tech/sqlite-based-databases-on-the-postgr...
Other than that it's awesome. I've stuck to its native file format though as scanning SQLite is slower.
Perform OLTP actions against sqlite db from within duckdb.
Perform OLAP actions against duckdb db from within duckdb.
Sometimes your OLTP content drives the OLAP query so read from both sqlite db and duckdb db at the same time.