You're talking in very vague terms here, what does """interesting""" mean?
Let me give you some numbers. Factorising RSA is order 10^6 logical qubits (and I'm being charitable here), simulating FoMoCo is around 10^7. The state of the art error correction is around (again, charitably) 10^3 physical qubits per logical qubit at the moment, that gives us 10^9-10^10 qubits necessary for the simplest quantum application. We're at order 100 right now.
Peter Shot thinks that error correction can go down to 100 physical-per-logical, that's an order of magnitude shaved off there, but the algorithm itself is pretty basic, i don't see it getting any better there. Simulation algorithms have much better odds in seeing improvements as I think the gates used there are rather non-standard and have avenues for better gate compilation techniques.