> Models of the human brain would likely be indistinguishable in every way, shape, and form from the real thing.

Eventually, but the more I learn, the more I think that's going to be an ethical nightmare to even test.

First brain to get the We Are Bob treatment is going to get almost every neurotransmitter slightly wrong, and be tripping as if they're suddenly alternating between ketamine/cocaine, LSD/antipsychotics, and every other pair of opposite impact substances you can think of.

I keep hearing doctors saying things like "we don't really know how general anaesthetic works" and "we don't know why sleep and dreams are biologically necessary, only what happens if you miss them" for example, and those feel like important things to understand when building models for simulation.