First 'tooth regrowth' medicine moves toward clinical trials in Japan
mainichi.jp
mainichi.jp
When I could finally move again (was paralyzed for a bit), and got to the hospital, they just told me to keep my mouth shut. Apparently, your tongue is just a muscle, so it will reattach itself.
It was a shitty few weeks, but at least I didn’t break any bones or land on my head.
I remember wondering how I’d ended up with a mouthful of sand and grit. It wasn’t sand.
Not sure whats worse.
Wait, what? Could you elaborate? How does that work?
Carrying around a note explaining why I couldn’t talk was also entertaining.
But the article makes it sound plausible that it'd work for normal adults too in that new tooth growth would occur. It's just unclear how/if they guide that growth to a specific area, or if it has to be wholesale replacement of the set of teeth like losing your baby teeth.
Maybe what will happen is once you get to a certain point of dental misery you just get on the medicine blocking USAG-1 and have all the remaining teeth pulled, then wait for the new teeth to grow in...
I guess it won't be simply as stimulate teeth growth like nail.
Yup. See this skull of a child with the adult teeth ready to come out and push the baby teeth out of the way (warning, some people find the image very repulsive, even though it's basically a textbook picture of a skull):
https://skeptics.stackexchange.com/questions/9541/is-this-im...
Teeth growth is a good target for such experimentation. Given its relatively easily operable nature allowing convenient observation of progress and intervention if needed.
We already can accelerate the regrowth of fingernails after losing one. This is the next easiest target if you ask me.
It sounded like they were doing experiments with transplants as well in one of the papers I skimmed.
I might actually prefer that approach if it had a high success rate, to replace a thoroughly trashed tooth. Seems preferable to exposing oneself to the new treatment for the entire duration of tooth development. Especially if all you need is one replacement...
I've got this, and 1% of people have this. I'd have to imagine that most of them would have obliterated the spot where they could grow these hypothetical new teeth by getting implants, though. So, I'd even think that it's really a treatment for children.
When I was a small child, it was already absolutely certain that I wasn't ever going to get my lateral incisors.
But sadly for me:
Once confirmed to have no ill effects on the human body, it will be aimed at treating children aged 2 to 6 who exhibit anodontia.Just curious.
Maybe not. Apparently implants are not common everywhere. I have a Chinese friend who recently got them in the US after an accident, he had some medical connections back home who said the procedure isn't very available in China.
Would she switch it for a grown tooth given the option? I dunno.
My wallet doesn't ask for who it was intended. It asks: Will it work and can I buy it?
And no, eating at different times won’t magically make your sphincter to your stomach close any tighter.
Stomach acid is also produced as reaction to food intake and other signals. Less acid => less reflux?
BTW probiotics have been found potentially effective by this systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019778/
This is probably not as simple as blaming the dysfunctional sphincter.
IMO early time restricted feeding shouldn’t be dismissed so quickly, it‘s potentially a fix for a number of systemic and gastric/enteric issues. The evidence is still weak but promising. The most important part here is „early“ - intermittent fasting usually has an eating window in the afternoon and maybe right until bed time. According to some (weak) studies, moving the eating window to the morning and early afternoon has vastly different effects.
Weirdly, I've also heard from people in that situation that more acid => less reflux because the sphincter only closes in high-pH environments. So one of the things prescribed can be hydrochloric acid supplements. Some people swear by them.
Finally instilled some healthy habits by 32, namely no excessively large meals and no eating big meals ~3 hours before bed and it magically disappeared.
I just had my first bout in a while yesterday - 2 smalls pizza is still 2 pizzas folks!
Also alginate based products create a raft that block the acid from physically coming up.
The early time restricted feeding stuff is very interesting, and new to me - but I did learn a lot about it reading this guys blog -https://caloriesproper.com/etrf-2022/
I'll check out the hiatal hernia exercises, thanks!
Other possible solutions: d-limone In one unpublished trial, subjects took one gram of d-limonene every other day for 20 days, on an empty stomach (that is, half an hour before eating or an hour afterward). A third of them experienced relief from their heartburn after a single capsule, and within two weeks 90 percent had relief. After a single course of treatment, relief lasted for up to six months.
Licorice The natural solution for ulcers, deglycyrrhizinated licorice root (DGL), can also be an effective acid reflux treatment. The suggested dose of DGL is two tablets, chewed about 20 minutes before meals, three times a day, or it can be taken shortly before bedtime if you suffer mostly from nighttime acid reflux. Use only chewable DGL—it must be mixed with saliva in order to be effective.
IQORO - It's like a pacifier put behind lips and pull.
inspiratory muscle training
Throat Band https://blog.fauquierent.net/2014/05/cricoid-pressure-may-mi... https://www.accessdata.fda.gov/cdrh_docs/reviews/DEN130046.p...
and then the standard advice of inclining your bed / sleep on your left side.
In my case, that is exactly what it is (a hernia). Other people may have different reasons for it.
My issue is I can stop eating at 5pm or even 4pm but at night if I roll over on my stomach it pushes on it and I vomit up digest food. There's nothing like sitting bolt upright from that feeling as you aspirate into your lungs at 3am! Even lying on my side doesn't help I can feel acid pour into my throat.
PPI meds like Prevacid make me feel bad just an all around blah feeling. they are not supposed to be taken long term and I've read ppi medications may damage kidneys. I think similar to high blood pressure medicine it has some effect on kidneys and can even cause coughing due to it.
One weird quirk though is at my worst if I got sick with the flu my acid reflux went away.
So for now watch my diet, eat somewhat sensibly (almost impossible since everything is a trigger), and try not to eat too late.
Cost the 4 rearmost teeth on the top side not including the wisdom teeth which were prob gonna need to go anyways.
They got eaten away because doctors were negligent and now every time I move and get a new dentist they treat me like I treat my mouth like shit.... Nah, I just had most of them damaged by literally thousands of liters of stomach acid, bile, and black stuff which was apparently blood from somewhere they can't see scarring on now... thanks doc.
Anyways I guess that my way of saying I sympathize.
Beef chicken and pork (other meats untested, manual exposure testing required) ALL nightshades (potato's tomatoes peppers etc) the Entire Carrot/Celery/Parsley family (it's big) Lettuces (ridiculous, it's just water!) Rice Oats All berries All tree pollens including that contaminating food.... (This is the real kicker, as it hurt worst when ingested) And some uncommon stuff is honestly always forget even existed and then get freaked out when I realized I missed it on the list
Thankfully they all went away, supposedly due to age related changes to body chemistry.
Oh boy, "the list"... Here goes a simplified version:
Beef chicken and pork (other meats untested, manual exposure testing required)
ALL nightshades (potato's tomatoes peppers etc)
the Entire Carrot/Celery/Parsley family (it's big)
Lettuces (ridiculous, it's just water!)
Rice (and related)
Oats (and related)
All berries
All tree pollens including that contaminating food.... (This is the real kicker, as it hurt worst when ingested)
And some uncommon stuff is honestly always forget even existed and then get freaked out when I realized I missed it on the list
Thankfully they all went away, supposedly due to age related changes to body chemistry.
歯 - tooth
生え - grow
薬 - medicine
why does this seem to be another ball game?
I do what I'm told to do. Yet as the years pass it's been cavities, root canals, extractions, crowns, and everything else.
The worst part isn't even the procedure, it's the cost (in the U.S. at least!). Thousands and thousands of dollars any time they need to do anything. And that's with dental insurance. They like to deny claims.
Dental should be covered under medical but that's an entirely different story. For now, I hope science keeps working on this.
It’s depressing, honestly.
Dentistry (though not optional orthodontics like cosmetic braces) in NZ is free until you turn 18.
The day you turn 18, it becomes private care only, and it's entirely out of pocket - just as you go off to university and have no money for 3+ years.
And yeah, vision checkups are pretty important to: regular checkups find problems inside your eyes that will cause blindness later.
The US seems to do an absolutely horrible job of preventative healthcare. Here in Japan, everyone gets a free yearly health checkup that looks for all kinds of issues; it includes blood, urine, and stool testing, and also includes hearing and vision checks, abdominal ultrasounds, a chest x-ray, etc.
You should have the knowledge required to advocate for your own outcomes.
I’m not affiliated with them, but I think that bristle health is a step towards that reality.
They offer oral microbiome testing and suggest personalized treatments to fix issues like cavities.
I never asked any questions or tried to understand why I got cavities (in part cos of the cost). It was just... I have bad teeth, it is what it is. But it's not. there is allot you can do, foods to avoid, drinks to avoid (beyond the obvious). But things are getting better, some dental hygienists are on YouTube now, who teach how to look after your teeth.
But yeah, still pretty dry out there, but better then a few years ago. Probably more on tiktok... but that's tiktok.
That paste used to make me really sick but wow it does work.
Not sure if they still have this though because the neolibs have destroyed the state health system and replaced it with mandatory private insurance that doesn't include dental anymore.
Also General Jack D Ripper has concerns about the impact to P.O.E. ;)
It's something that really helped, my dentist joked about being put out of business :P My parents' generation have really bad teeth that started going bad in their teens already.
It was indeed only for kids, the dentist said the enamel no longer absorbs it when the teeth are fully grown. But perhaps this has been disproven now. I'll ask my current dentist about it.
I still get fluoride treatments from my dentist but now it's something he paints on, perhaps the same as what you've described.
Anyway, according to a dentist friend, whether you get cavities is also dependent on the natural groves in your teeth. Some people's genetics cause them to have more cavity prone teeth than others.
I was worried too about swallowing it but it was also the smell of it that made me sick. It was very strong. I really hated it.
And yeah I guess I'm not very prone to them, but it's very clear that the generations before me had much worse teeth than we do.
Brushing times can also help and always floss at least daily.
If you're interested in learning more I would check out the teethtalkgirl YT channel. It's a great way to learn a heaps about teeth without paying $$$ at the dentist asking questions. (but you should still go to the dentist)
Anyway, that's my 2c, best of luck, teeth are the worst.
If USA based maybe Mexico or Colombia also a good closer choice?
My dentist (in UK) charges £2500 for an implant. I don't have insurance.
(technically I do have insurance, since NHS dentistry exists which I pay for in my taxes. However I had an NHS dentist and when they got sold on to Bupa they would simply not do things which would be expensive for them, meaning after some years I had fillings falling out and broken teeth all over)
Dental insurance in the us usually only covers a max of $1000
At least for anything students can work on (fillings, extractions, etc). If you need a root canal, ortho, jaw surgery, or etc then I doubt it'll be a great option.
But what do you mean with do as your told? What do you use to clean your teeth? What toothbrush to do you use? What are the ingredients of your toothpaste?
What is the average PH of your mouth? Do you have acid reflux often? Do you eat sweet foods or flour i.e. simple carbs often? Do you eat a lot of fruits or salads before sleep?
I've had a long history of cavities until I actually started paying more detailed attention to what I eat, what tooth paste I use etc. None of that is stuff any of the dentists I went to ever told me. I panicked when a piece of my tooth broke off almost a decade ago.
BTW there is a treatment before you have to do root canals, I forgot the name, and most dentists don't do them. There is also a chance that it doesn't work and I assume that that's the reason why dentists don't generally offer it. I forgot the name but you can surely find it by googling. For a lot of people myself included don't an artificial gum transplant for receded gums also massively reduces exposure to dental issues.
There are certain calcium phosphote combinations like the Novamin thing that GSK bought and then forbade everyone else to use or Hydroxyapatite, which is sort of artificial dentine.
When my root was exposed I did apply clove oil and completely refrained from simple carbs for the treatment and after until it healed.
EDIT: a lot of Japanese tooth pastes also have it by the way and there is no real guarantee that it works, but theoretically it's supposed to fill microabrasions temporarily.
* It used to be more popular to remove wisdom teeth. Opinions seem to have changed on this over time, I've never had mine removed, in my 40s now and so far so good.
* I had a small crack in one of my molars and saw a dentist who said a crown would be necessary. I was skeptical and got a second opinion. The second dentist immediately said "It's small and I don't think you need a crown for this" and did a filling instead. Eight years later, so far so good!
* Even FLOSSING was removed from the U.S. Department of Health's recommendations several years ago because there is a lack of evidence that it's effective! (I still floss around a couple of teeth every day in places where food likes to get stuck.)
To do a crown the dentist has to grind down your tooth into a stub and irrevocably destroys the enamel in the process. To me an unnecessary crown sounds like borderline malpractice. I wonder how many other unnecessary procedures dentists are doing for the $$$$.
I know that when I don’t floss, my gums will bleed sometimes during brushing and/or they’ll get inflamed. When I do floss regularly, absolutely no issue with bleeding or inflammation.
It’s so clear to me that I can’t imagine what the difference is between my anecdata and whatever actual data is coming from these studies.
Do they bleed during flossing though? I used to get bleeding gums after brushing teeth, but switching to a softer toothbrush stopped it. Flossing, at the start, does cause my gums to bleed though.
After that, I never bleed during flossing. And I make sure to get it up between the gum and each tooth, so there’s a decent (but appropriate) amount of floss/gum friction.
My dental hygienist knows when I have been flossing and when I haven't.
If they start bleeding again it's a sign I've not been doing a good job staying on top of keeping them healthy.
So this doesn't necessarily mean that flossing doesn't work. It may just mean that dentists are already making money hand over fist and don't care enough to do good studies and validate that.
BTW what was specifically looked at was whether unsupervised flossing works. So another possibility is that flossing properly works but a lot of people do it ineffectively.
All things you would want a conscientious, science-based ADA to care about
Dr Mike Mew, of 'Mewing', faces misconduct hearing - https://www.theguardian.com/society/2022/nov/14/orthodontist...
It seems a lot in dentistry of what does or does not need to be done is subjective.
Even the pushy dentists have rarely recommended removal of wisdom teeth unless they are trouble. I mean if it's pushing inside the muscle area towards bones or screwing up things for other teeth you have to. If it's forming a cavity area (like in my case) you definitely should get rid of it.
Wisdom tooth removal is not rite of passage. It's need based and often the needs are real and very much "needed".
> Even FLOSSING was removed from the U.S. Department of Health's recommendations several years ago because there is a lack of evidence that it's effective
This is bizarre because I can feel the change in my mouth everyday with and without flossing. I am not sure there is a need for some kind of empirical evidence here. Especially if there are not gigantic mountain pass like gaps between your teeth.
Yeah the crown job recos are often con jobs. Whenever I have been advised a drastic dental job I visit a Govt or a charitable medical college dental hospital here (India) and get a consultation. I do not get "polite" or "sophisticated" service there :D but I get honest and expert to the point advice.
In theory if you think in an evidence-based way your positions on flossing and multivitamins should be about the same, which is interesting.
What's really important though is that the profession of dentistry has not felt the need to fully study and establish the benefits of one of their most foundational recommendations.
Every dentist tells you to floss yet they have not bothered to establish reliable evidentiary proof that it works. If they don't care about evidence when it comes to flossing, what other procedures are they pushing without solid evidence of benefits?
The hot take way of saying this (and I do kind of believe this) is that dentistry as a medical science is in its infancy, and as a result, dentistry as a profession/business is partially snake oil.
All that said I have had one crown including a root canal done in my life, the need was clear and it was done well and professionally and I'm happy with it. So I'm not saying that everyone should ignore dentists but this imho is an important place in your life to consider getting second opinions and steer towards professionals who are less profit-driven when you can.
I have ADHD. I hate flossing, and I'd put off flossing to the point where I wrecked my sleep cycle and tended to end up just not brushing my teeth before bed.
Ever since I stopped flossing, I've basically always brushed my teeth and have kept my sleep cycle more successfully.
Yes, I know this is potentially very bad dentally, but frankly I'm sick of having a catastrophically unreliable sleep cycle due to my mental illness and I'm willing to accept half-assing it if it means it doesn't destroy my life.
That said, I have no particular opinion on the evidentiary base of flossing - my dentist has always recommended I floss, and I believe his recommendation. I would floss if I could.
It seems to be doing something, and can't possibly be worse than my previous flossing regime which was: "twice a year the day before a dentist visit".
I wasn't willing to shell out for the name-brand water flosser, other options do the same job at the same water pressure for 1/4 the cost.
It took about a month to move up through the power settings. Start on the lowest and click it up when that starts to feel a bit tame.
I've now been using this thing for 6 months, it's just about time to find out whether I get my bi-annual nagging about the importance of flossing. My personal opinion: Cochrane's probably right, flossing is most likely bunk, but I'm pleased to have found a way to do it that I can stand
I do the whole shebang as a curtesy to others, and I hope they will return the favour.
I think that whether flossing is useful or not is highly dependent on the space between your teeth. I have small gaps between my teeth, and I floss three times a day. I can see the food come off on the floss. My father never flosses (jus brushes0, and never has any problems with his teeth, but he has large gaps between his teeth. Presumably, the bits of food just fall out.
A lack of evidence of course is not the same as no evidence.
The dentist is in this regard a unique animal.
That doesn’t sound necessarily bad — insurance is for the extraordinary events anyway, right? But when my kid had his wisdom teeth out or I was hit by a car and needed a crown to hold a damaged tooth together, my regular health insurance covered it, not dental insurance.
Eat a carnivore diet and your tooth issues will go away. At least try to eat only real foods, never add any added sugar into anything and avoid all processed foods (treat rice and pasta as processed foods as well, they are not real foods!).
There are plenty of books out there that show that for all indigenous tribes, as soon as they got into contact with western civilization and started eating a carb heavy diet (beer & grains), their teeth rotted away within one generation.
If it were only related to contact of food with teeth, wouldn't rinsing your mouth after eating achieve the same effect as any diet like "carnivore diet"?
And by “carnivore”, do you mean specifically including meat? Or do you mean something completely different, like a ‘varied & balanced’ diet?
I find it odd to list the biggest change in a move from a more tribal to a more westernised diet as being “beer & grains”. I would have expected the increase in sugar and chemicals/preservatives to be the relevant factor.
I saw them for awhile and we got friendly. He was a younger guy and told me that he was probably one of the few honest dentists in the area because his pay wasn’t dependent on high dollar procedure to make enough to keep a practice open. Apparently, unlike medical insurance, dental insurance pays pittance for most things, so upselling procedures is how dentists really make money, usually.
Best dentist I ever had. Rarely did I need more than regularly scheduled cleanings and when I did he always started with the least invasive options (I grind my teeth in my sleep and before I realized it and got a guard there were complications)
I miss that guy. I’ve been suspicious of dentists ever since and look for signs.
> I miss that guy. I’ve been suspicious of dentists ever since and look for signs.
Now you can imagine how the avg person sees the cloud spaghetti coming out of a trendy boutique - being informed their 'perfectly fine' BSD box and ZFS setup needs to become a latent chain of 900ms microservices.
Some cases it is the play, but often it's RDD from new hires or grifters.
The first recommended I get eight fillings (which is why I went to the others).
The second recommended I get two fillings (which I did get).
And then the third recommended I get none.
Needless to say I'm now also suspicious of dentists.
I've got pretty good teeth, but am certainly wary of some of the recommendations I've had. Did have to have a molar out (hole all the way to sinus), no doubts there. The regular dentist said, "hey, you should get a bridge!" The specialist who did the removal and bone graft let me know that was the worst possible choice. Better to leave a gap, or get an implant if I want, but a bridge is caps on the adjacent teeth that will eventually wreck those teeth too. So him, I trust.
Making a titanium implant or just leave it is the best option. Only if you are over 80 years or have some other issues (making it more risky to do the implant operation) should you go the bridge route instead of making an titanium implant.
To make a bridge you have to destroy (grind down into cones) two teeth adjacent to the bad/missing tooth onto which they glue the bridge. Crazy. On top of that you will forever have issues cleaning below the bridge which probably also causes your other good teeth to decay as more food and bacterias are sticking around.
They found all had widely different recommendations on the number of fillings required.
Funny that I went to the dentist in my home country just before I moved and they said all good. Went to another dentist (which I'm still with and absolutely love) and over past 4 years we haven't pulled a single wisdom tooth and I still don't have a night guard.
I'm not sure how involved this new teeth growing process is, but I can imagine it's not going to suck as much value out of you as a dentist can. Perhaps this isn't even done at the dentist (I hope so actually.)
I always felt like I was getting screwed by my dentist, but then I walked through a, what we'd here call a "volksbuurt", a neighborhood that isn't particularly rich. Saw a dentist, and it seemed more like a community place. I walked in, registered and have loved it ever since. They think along with me, tell me to get insured because something big is coming up next year and they can shift the current work to January (when the new insurance starts), they are very transparent about cost, explain why things are needed. I really appreciate that. They even told me that the pain I experience can go away without any major intervention if I really started to floss daily, it worked indeed.
Similar stories exist for garages (the place where they fix your car).
Once I started with the night guard I got even more pain and after a month or two my tooth cracked and had to be repaired.
As there is even less space (as you have the plastic stuff between your teeth now) it seems you press even harder which damages the teeth even more. Maybe against light grinding movement it can help, but against pressing your teeth hard together at night it does definitely not help.
The best advice I got was to remind yourself at night when going to bed (and during the night when you notice it) to open your mouth a little (still with the lips closed) so that the teeth do not touch. It's a habit thing. I also noticed I grinded/pressed my jaws together more if I went to bed late.
>This article originally ran in the February 1997 issue of Reader’s Digest.
I decided just to go see my local UK dentist. Shabby office, black and white x-rays. They said all my fillings were perfectly fine and showed me on the X-ray what they look at. They also told me the gum wash (which cost $150) was unnecessary.
That was 6 years ago and I haven’t had any issues with my teeth.
Maybe somebody knows what this procedure is called?
Which appears to be a purely aesthetic procedure.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD...
I'm curious if that still holds over say 5 years. And how does it intersect with other practices. For example are people who don't floss religiously more likely to benefit from more frequent cleanings, etc.
There was no waiting around in waiting rooms, it was a top notch service in every way.
My only concern which I found out recently, was the increased used of xrays to check the teeth can increase the incidence of thyroid cancer.
Another dentist I knew who wrote their own software even said my dentist was expensive.
You get what you pay for.
My story is only about my doctor wanting to do additional x-rays because I had new insurance. She saw it as a way to get paid and I was already tired of getting offered another service at every visit. I told the practice I didn’t want another set of x-rays 6 months after my last when my insurance allows every year just because I had new insurance. You would have thought I had offended them, hygienist, front office and dentist all tried to change my mind.
Learned later about how cavities work and figured out the best routine for my teeth - floss and then brush (Philips electric toothbrush) every morning. Brush and then fluoride rinse every night. I always floss/brush before breakfast, and wait at least 30 min after dinner to brush/fluoride rinse.
I haven’t even had a cavity in 5+years, and my dentist always says I don’t even have any plaque to scrape off - “you have good dental hygiene, and I don’t say that very often”
To f*ck your oral health, you need carbohydrate + an acidic environment.
So you could grow teeth in-vitro from patient's own stemcells and then implant those. I would be safer and not much testing needed.
Treatment consisted of a breathable dressing which sealed the fingertip around the stump, thereby prevented it from drying out and scarring.
It was very smelly and messy for a few weeks, but it worked - my fingertip grew back.
It's a bit deformed (because the emergency doctor gave me a 'manicure' before dressing the wound), but it's there.
Lots of results on Google if you search for "fingertip regeneration". Otherwise, I can provide academic/medical references.
How about as recent as George Washington? [1]
[1] https://www.mountvernon.org/george-washington/health/washing...
wild
Yes, a social system in which your involuntary labor all goes to your "owner" and in which you are reduced to selling your teeth for spending money is an abhorrent one.
It's capitalism ad absurdum. Sure, today people are born "free", but they still have to pay money to keep a roof overhead and food on the table, and that same money can be used, say, for dental procedures that could save teeth, so in a way people still have to make choices about whether they'd rather have money or teeth. They just also have more options for getting money. You can still see the impact of these forced choices in poor people's mouths.
The beneficiaries of this indirect coercion -- when restricted to the subject of teeth -- are today mostly dentists, and the actions chosen are mostly inactions (skip treatment, get a cheaper treatment). In those days, the beneficiaries included people who needed dentures, and the actions were less passive: They involved submitting to pliers.
On the ethical spectrum, it's somewhere quite a bit worse than buying a wig made of a Pakistani lady's hair, but better than buying a Chinese prisoner's kidney.
Also seems like there's evidence of the practice going way back to ancient Egypt, which isn't hugely surprising but it's crazy that this is something established for at least as long as good old cruelty-free metal teeth [2]
[1] https://en.wikipedia.org/wiki/Tooth_transplant
[2] https://www.livescience.com/46788-ancient-dental-implant-fou...
(Edit: The history section of your Wikipedia link [1] is interesting.)
Is there any known successful case?
Unless you install into fresh socket, the success must have been because of bone-to-bone adhesion.
>The first stage begins in the fetus at about 6 weeks of age. This is when the basic substance of the tooth forms.
>Next, the hard tissue that surrounds the teeth is formed, around 3 to 4 months of gestation.[0]
[0] https://www.hopkinsmedicine.org/health/wellness-and-preventi...
The reverse of how we think it works from external observation alone.
It's totally normal to think they grow like nails, but only twice.
On the note of dental hygiene I recommend, in addition to the standard stuff:
1. Rising your mouth with water immediately after eating. If you’re at a restaurant just drink some water, swish rigorously for 15 seconds and swallow.
2. Flossing regularly soon after eating. Couple with a water flosser if possible.
https://www.oralcare.co.jp/faq/cat2/ (page is in Japanese)
Sensodyne has a bioglass (sometimes called hydroxyapatite, NOVAMIN, or Biomin) which is what you are describing however it's excluded from the Sensodyne sold in the US. The reason why is a long story [1] but if you want "good" Sensodyne you have to import it from literally anywhere else or buy a no-flouride biomin version (made by Dr. Collins who decided to go through the FDA process) in the US. Both are luckily pretty easy to get on Amazon however there's a bit of a markup.
1. https://medium.com/@ravenstine/the-curious-history-of-novami...
The biolgass ones aren't really "restoring enamel" but they "refill" (remineralise) the enamel with all the minerals that slowly leach out before the enamel actually wears away.
The flouride toothpastes act by hardening the structures those other minerals make up which increases the resistance of your teeth.
They both do different things but they work well together. In the US you won't find them both in the same toothpaste (only Biomin C/without flouride is FDA approved) but outside the US you can find Sensodyne with NOVAMIN and flouride as well as Biomin F (with flouride).
So depending where you live, you might want to give them another shot but making sure you use both bioglass and flouride (I personally do a dot on my toothbrush of both Dr. Collins Biomin Restore and Colgate PreviDent 1.1% NaF 5% KNO3). At least for me it has worked a lot better than just doing one or the other.
You can't get high PPM fluoride without getting a prescription unfortunately.
https://www.colgateprofessional.com/dentist-resources/caries...
Aren't they generally less effective than flossing with threads?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236551/
I’d still use both as the abrasive action is likely to catch some things water cannot. And water able to reach areas more easily string cannot.
Irrelevant anecdote: I had cavities as a preteen but none after. My dental hygiene is non rigorous brushing at least once a day, more if a tooth begins to feel sensitive. Last dentist visit 20 years ago.
Nano hydroxyapatite combined with fluoride has a little bit better evidence for it being better than fluoride alone.
https://scholar.google.com/scholar?cites=6855835701389665111...
"TNT" out of Ohio State: https://en.wikipedia.org/wiki/Tissue_nanotransfection ; direct (epithelial,) stroma reprogramming
Regenerative medicine: https://en.wikipedia.org/wiki/Regenerative_medicine
From https://www.ada.org/en/resources/research/health-policy-inst... :
> What share of U.S. children and adults have dental benefits?
> Dental benefits coverage varies by age. For children ages 2-18, 51.3 percent have private dental benefits, 38.5 percent have dental benefits through Medicaid or the Children’s Health Insurance Program (CHIP), and 10.3 percent do not have dental benefits. For adults ages 19-64, 59.0 percent have private dental benefits, 7.4 percent have dental benefits through Medicaid, and 33.6 percent do not have dental benefits. Source: Dental Benefits Coverage in the U.S.
TIL about Dental lasers: https://en.wikipedia.org/wiki/Dental_laser
What percentage of dentists offices have lasers in the United States? https://www.google.com/search?q=what+percentage+of+dentist+o...
FWIU, dental lasers cost from $4-40K per unit, per station in the office; and they may be tuned for specific applications or general purpose. There's a waveguide to guide the beam; and there are new waveguide methods for steering photon beams through opaque tissue (with e.g. dual beams).
"Scientists Have Discovered a Drug [Tideglusib] That Fixes Cavities and Regrows Teeth" (2017) that's already FDA approved for Alzheimer's but there are yet no clinical trials of it as a cavity fill?? https://futurism.com/neoscope/scientists-have-discovered-thi...
Tideglusib: https://en.wikipedia.org/wiki/Tideglusib
Can teeth be grown in molds from e.g. stem cells, or nanotransfected tissue with/without a 3-d printed scaffold or [...]?
Dental care probably has direct returns in labor productivity?
Embrace Tooth Regrowth Serum Salesman.
Most dentists that I've been to have more business than they're able to serve, so I suppose their client base won't dry up too soon - especially that such procedures are bound to be expensive - at least initially.
Then there's orthodontics, because who says that this new tooth will grow perfectly straight?
Consumer warning: might cause drowsiness, or anxiety. Teeth growth is guaranteed, but the location of newly grown teeth is not. Consult your doctor if you have high blood pressure, pregnant, or breastfeeding. Do not take with alcohol.
Teeth growth is guaranteed, the location and the shape of newly grown teeth is not. Expect replacement teeth to be distinctly sharper than your existing molars. Use caution when chewing. Although rare, some patients experience changes in appetite that can be permanent. Avoid swimming and contact your doctor if you experience strong cravings for raw meat, or a noticeable increase in desire to bite people or pets.
> Unlike humans, all sharks are born with teeth. They grow in conveyor-belt rows, with the biggest teeth facing outwards. Over time, the smaller teeth in the back move up, replacing the front ones. Most sharks have between 5-15 rows, and the whale shark has a whopping 3,000 teeth in its mouth!
Not sure if you'd want that!
If a child is not fed enough tough foods, then they end up not using and developing their facial muscles correctly.
If those muscles which should be guiding the jaw into it's correct position aren't being used correctly, they end up causing the jaw to not develop properly. Now you end up with a mouth-breathing child who has a reverse swallow, crowded teeth, and is going to need braces, a retainer, and possibly a CPAP machine.
Afaik here in Spain is rather common to have your wisdom teeth pullet out (I have), and it's the first time I hear this theory.
Otherwise, it's just a matter of time before any doctor (or layman) will be able to pull damaged teeth and then easily regrow them, avoiding the endless thousands that would be otherwise charged for dental repairs.
I'd sure like to know that the person pulling my tooth knows how to evaluate it with an x-ray to see if it really needs to be pulled (and to see if the bone structure beneath it is healthy enough to regrow a tooth), and is trained to administer appropriate dental painkillers. If I asked my primary care physician to do it, I'd expect him to refer me to a dentist.
Brush your teeth and keep the floss handy!
> Once confirmed to have no ill effects on the human body, it will be aimed at treating children aged 2 to 6 who exhibit anodontia.
This greatly limits usefulness of the whole enterprise. The problem is that this condition is not likely to be found at that age, it's found later when the problem is evident to parents. What is actually needed is some treatment for teenagers or young adults.
Have you ever seen a wild animal with bad teeth? Darwin makes sure that nearly all wild animals have perfect teeth.
Humans would too if we ate our natural diet of mostly fruit and some meat.
Wouldn't that be every dentist's nightmare? Who gonna want that root canal or crown when they can just pull + regrow?
congenital = abnormal.
Mean it only works if you never had teeth, not when you had yours removed.
Could be funded by tooth fairy receivables.
Reall? Dentists prefer rotten teeth which takes a lot of money to fix.