From plant life and human health all the way up to nation states, there are lots of people doing great work just making sure that things keep running smoothly.
Sure there’s vast numbers of people doing great work that isn’t innovation and creation.
You’re dismissing the insights here too quickly if you’re just wanting to find fault with the intersection of the term “great work” with all the people in the world doing all sorts of different types of great work.
This is about creation and innovation as great work.
I know people who are perfectly content following obscurity with curiosity and the world would not consider them successful by monetary measures.
It's similar to the Rogue Bees: https://www.mrdbourke.com/what-if-you-did-the-exact-opposite...
Although rogue bees (as a small portion of the population) are actually essential to a hive's survival.
The guy invests money in and profits from other people doing "great work". So it shouldn't be too shocking his primary focus is on the commercial or the innovative.
If you can dig ditches faster than anyone else, then you're a great ditch digger, and you're doing great work. Similarly, if you're a surgeon who saves much more lives than the average, you're doing great work. Etc.
If you want to have a successful internet business, code in lisp.