Sucralose saw a recent study on effects of DNA that are more compelling than Aspartame. Acesulfame-K messes with pancrease and insulin signalling, Stevia has other detractors iirc... etc. etc.
In the end, it's all a mixed bag, and who knows if it's actually better or worse than consuming more than 25-40mg of fructose or alcohol in a day. There are massive corporate interests in all directions with deep revolving doors in regulatory and research bodies. It's effectively impossible to know.
Is it a variety/strain of food that was considered "food" 250+ years ago? Probably safe. Is it a new strain that has a multiplier of hystamine or other negative hormonal responses, or in a consumption that is a multiple of 250+ years ago? Probably not safe. That's my take.