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While the principles still hold true, I think the Google Best Practices are a little more up to date:

There are also companies that can automate these best practices for you. Check out my company, http://torbit.com for example.

Are you guys mostly focused on larger sites right now? Is pricing in the same ballpark as a Cloudflare type service?

we're mostly focused on large enterprise customers where speed is actually quantifiable in dollars.

Yes, I once installed Google's page-speed to suggest and reduce our company's slow website.

Still the best one out there I think.