(after looking at corescore probably not, as it'd be way too expensive. that being said, the DE-10 Nano is getting old, are there any potential successors coming)?
But, in better news, it looks like Intel is finally getting off their asses and actually expanding their newest Agilex series to meet their customers across the spectrum, and finally offer new alternatives to their Cyclone series, which is used in the Nano.
Sometime later this year they are planning to announce the "Agilex 3" line, and that -- or the already announced "Agilex 5" -- will likely be what you will see in the successor to the DE10-Nano. It will still take work to target this chip and get it into a board people can readily buy.
https://www.digikey.com/en/products/detail/amd/SK-KV260-G/13...
The price is very good for Ultrascale+.
I think something could made cheaper using an Efinix Titanium chip, someone should do it. Their own dev. board is too expensive:
https://www.efinixinc.com/products-devkits-titaniumti180m484...
I am keen on the MiSTex project though. The plan is to come up with something that is more flexible than MiSTer to support different targets. So for example, you might be able to target a simpler core to a simpler device and vice versa.
… OP didn’t mention they were optimizing for price.
Some might say it makes sense to optimize for availability, recent updates to hardware software stack, etc.