I have tried it, but for whatever reason I just don't like it. I prefer just running tmux in iTerm with no integration.

On the topic, you can also integrate tmux with the native clipboard - I have set copy-pipe to the remote pbcopy, so any selection done in tmux get copied to my local clipboard. I also just found out that tmux also support it natively (https://github.com/tmux/tmux/wiki/Clipboard#the-set-clipboar...).