I do think finding extremophiles in the solar system is a distinct possibility (Titan seems like a good bet) but I'm doubtful any of it will be multicellular.
I'd bet (at least a small amount of money) that life, at least the most basic unicellular life, will pop up wherever the requisite materials exist in environments where they're not immediately destroyed but have enough external energy to facilitate some more energy intensive chemical reactions.
Jupiter's atmosphere (to me) seems just as likely a place for life to form as the surface of Titan. It would be harder for us to find that life since the environment is so demanding compared to our level of technology. The surface of Titan or Europa are much easier exploration targets relative to Jupiter's atmosphere.
Go to high enough pressure and the very polymers of life begin to break. It becomes energetically favorable for proteins to be decomposed to individual amino acids, due to their now exposed charged ends assisting in compressing water.