Then the question is: can you actually use the extra interior space?
Then the question is: can you actually use the extra interior space?
This becomes obvious when you take it to the extreme. A cube of 10 × 10 × 10 meters can be divided into 1000 units of 1 cubic meter each, and has an external surface area equal to 6 × 10 x 10 = 600 square meters, or 0.6 square meters surface exposed per unit.
A solitary sphere with a volume of 1 cubic meter has a radius of 0.62 cm and a surface area of 4.836 square meters, which is over 8 times worse, even ignoring the fact that it's harder to utilize the space in the sphere.
Plus, the curvature would be “wider” for a larger building, which would make it a little easier to design or arrange furniture.
Even if that wouldn’t make them so undesirable as to be basically useless, that probably would be in conflict with building codes in large parts of the world.
the best you could do is a fairly small sphere with kitchens, bathrooms and storage spaces in the inside.