There's a group who're trying to get Mayan orthography into Unicode. Mayan has some challenges; the two I like best are:

1. Rendering is in pairs-of-columns, with a "Z" layout; and,

2. Glyphs have a concept of depth, and you must render subglyphs with the correct depth and occlusion to maintain meaning.

Mayan also has the same feature as Egyptian Hieroglpyhs (but not the same extent) of multiple glyphs per word/logograph/letter.

Here's a 2018 proposal, that covers all of this in more detail:

https://www.unicode.org/L2/L2018/18038-mayan.pdf