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The aesthetic beauty of nature is usually used as an argument in favour of intelligent designers. Obesity does not fit in with that aesthetic beauty. If there was an intelligent designer then it is clear that he left a lot of bugs in the design. The design appears to be highly adapted to a certain environment and now that humans have left that environment the intelligent design starts to fall apart. The design needs to be adapted to the new environment.

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I believe the religious reply to this would be that G-d created us as unique individuals, with our own ways to contribute and our own unique growth path that requires overcoming unique challenges.

Eg - your unique path in life maybe unlocked by figuring out how to handle your predisposition to obesity, while mine may require working through emotional baggage or whatever.

If we persevere, we not only avoid the problem but level up in our development.

Unique individuals , yes. But we all function the same way. This is why calories in / calories out is a constant among all unique individuals.

Correct. But we differ in how hard it easy maintaining that balance is for someone.

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