Chris' point about native code in Python reminds me of when the Chakra JS engine devs pleaded with Node.js library developers whose packages also contained C++ to port to something else. That was a tall ask then...
This is an interview with Chris Lattner; I was more interested in directly hearing van Rossum talking about Mojo.
trigger warning: this is a Lex Fridman link, so you might want to avoid it if you dislike him