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Comment by mtlmtlmtlmtl | Hacker News Reader

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mtlmtlmtlmtl

Too bad it's also a laxative.

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Clears shit from both your body and your mind, at the same time :)

Magnesium is too, to a degree. With age, this is often a good property.

There are plenty of opioid analogues to decrease it safely.

Mag isn't too bad, I believe you also get acclimated to it (haven't taken it in a while).

IME it's not much different from having a fiber-heavy diet.

With magnesium it's more the specific salts that are laxative. Like the oxide which is both a laxative and has a low bioavailability. Citrate in huge doses is used as a laxative too. On the other hand, I have good experience with the orotate. Lactate and gluconate should be good too.

Bisglycinate is supposed to have the highest bioavailability.

And IME zero laxative effects. Citrate in normal doses is also okay

Magnesium amino acid chelate is best for most, especially magnesium di-glycinate.

Magnesium supplements have laxative effects as long as they are not absorbed. More bioavailable forms of magnesium do not exhibit laxative effects in normal dosages.

I think magnesium can also lead to other issues related to cardiac arrythms. I have no direct source to point to however.

The study dosing was 1mg/day, compared to the standard dose as a laxative of 2mg.

"In this study, we used a low dose of prucalopride (1 mg as opposed to the licenced dose of 2 mg) to reduce the risk of side effects. At this time, we currently lack information about the optimal dose of prucalopride needed for occupancy of brain 5-HT4 receptors, although data from our previous reports indicate that 1mg is sufficient to demonstrate pro-cognitive potential."

I'm not quite sure if laxative is the correct description of this drug, even though it's official one. It is used for treatment of constipation in cases where laxatives don't help. I'm not sure if it has any similar effects in non-constipated people as other laxatives have.

So's Lexapro for some people.

(Me. I'm some people.)

That's funny, the main side effect for me was inability to urinate.

I've had both feelings from MDMA. Urgent need for #2 on come up. Complete inability to perform #1 even though busting at peak. Maybe it's a serotonin thing

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