So what I’m wondering is how people in these trials deal with the depressive effects after it wears off. Or are the dosages so low it doesn’t matter? I see no mention of this in the article.
Depressive effects aren't typically the greatest concern with this population. The risk to manage is traumatic material and sensations coming on more strongly afterward and overwhelming the person's capacity to regulate. This is one of the reasons the trauma informed psychotherapy aspect of the treatment is important.