I've tried previous iterations of the Bose QC line but I was disappointed by a) the battery requirement, b) the sound quality (poor and muddled by active noise cancellation) and c) the build quality---my pair died after a year and those things never did anything but sit at my desk.
I'm going on five years with my HD280s and I don't have a single complaint.
edit: I should add that I do end up using my iPod earbuds a lot. I should really buy another set of HD280s for work.