I regularly see small/medium websites which state they only work with Chrome, but I feel they do so at their peril.

I see some of those sites push people to install a "desktop app" if you do not use Chrome, which is of course an Electron-based app.

I also regularly see services that just fail for long runs of time on non-Chrome browsers due to complete lack of regression testing, or (slightly more generously) because they aren't testing their services against current releases of Firefox/Safari. Safari is more sensitive to this, both because of a much more active development tick compared to Firefox, and because it is leveraging system frameworks rather than a relatively static compatibility layer 'buffer'.