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Comment by rale00 | Hacker News Reader

You don't directly convert dosage across species like that. The dosage they tested on monkeys was 250mg/kg, and the human equivalent would be less than that.

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The basic formula from mouse to human is (X mg * (3/37)) = human equivalent dose in mg/kg.

In this case (1000mg * 3/37)) comes out to 81mg/kg. So, if you weigh 80kg, it comes out to 6.48 grams per day.

That's a lot of taurine, but not really a crazy amount. Easy enough to consume.

Is there a precise biological explanation for that factor, e.g. metabolism rate or something?

> oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function

The equation is from here: https://pubmed.ncbi.nlm.nih.gov/17942826/

For what it's worth, the rat equation is (X mg * (6/37))

Keep in mind that it's a loose/general guideline. Basically a starting point. But usually a quite accurate one.

When my son had cancer, many of the medication dosages were based on body surface area. Maybe it is similar to that.

https://reference.medscape.com/calculator/692/body-surface-a...

I see that Amazon sells 1 gram capsules of taurine (several vendors). So, yeah, not too difficult to consume. One brand I saw is about $0.08/gram, so it wouldn't be overly financially burdensome, either.

IMO anything you buy from Amazon that goes into your body should be considered at best fraudulent and at worst toxic until proven otherwise.

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