Intravenous Caffeine
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He chuckled a bit and told a tale of when he actually had that show up on his hospital visit once.
He was in the hospital for some reason. That next morning he was rather grumpy and after snapping at the doctor apologized and noted that it was 2 hours after he normally had his morning coffee... which he couldn't have. The doctor asked if he'd be better if he had some caffeine and the manager said "probably."
So T43.616A showed up on his chart and shortly after that a nurse came by and added one cup of coffee caffeine equivalent to his IV. Apparently it degrumped the manager sufficiently shortly afterwards.
The IV was much more than the cup of coffee from Starbucks and there was some dickering with insurance about if that was a necessary or elective treatment.
He concluded with that he wouldn't recommend it again.
> The IV was much more than the cup of coffee
To be clear you mean about same concentration i.e 100mg but higher absorption?
I think he means that the IV caffeine cost much more than a cup of Starbucks would have.
Probably 'nil by mouth' (pre-op or something) not just no fluids/coffee.
I don't know why now and why this, but this has convinced me that I really need to cut down on what I read online. 99% of it does not go towards my life objectives and 100% of it is probably taking up space in my brain. To be clear, I would have laughed at that fact and moved on before. It just hit me differently today; I could be thinking about my family, work, friends, whatever, but now I know some irrelevant fact about ingesting drugs via the butt.
Seems a little funny to go through all the trouble and extreme stigma of injecting yourself with an IV drug, only to pick ground up coffee beans as your poison of choice (!)
The study is interesting mostly for the fact that someone tried it, but ultimately the results don't show a very strong effect. I wouldn't put too much confidence in how well it would replicate either, these kind of studies can have a lot of variation.
>Every drug seems to have a “right” way to take it. You [...] booty bump ecstasy
That is not really typical. People normally eat it as ecstasy pills, or as MDMA powder.
Most recreational drugs can be taken rectally, that usually makes for a higher bio-availability and a faster peak plasma concentration. Some people do that a lot, with everything. It is not specific to ecstasy, that I know of.
Not everyone is easy to start an IV on, especially if it's hard for them to hold still (like if they're in so much pain that they're considering between IV drugs or a suppository).
Better that pills in every way, except convenience.
Injection is still better.
Belladonna and Opium (B&O) suppositories are one of the best things that I've discovered. They were very reluctant to write me a prescription for them but they were life changing last time I had to pass a stone. Dunno what would happen if I asked for one outright... when I tell them dilaudid doesn't do much for me I get treated very skeptically.
Nowadays unless you're over 65 you'd be labelled with "drug seeking behavior" (in your records) and sent home with nothing and a "come to the hospital when you pass your stone." Forget the fact that the difference between drug-seeking behavior and legitimately needing something stronger is indistinguishable, and forget the fact that it will cost thousands upon thousands of dollars for you to do it in hospital. Thank God they're keeping you safe from the evil Sacklers
That is, it seems like nowhere else has the idea of purification through suffering really taken hold at such a widespread level for so long. I'd argue its because its just the flipside of the Prosperity Gospel. If you assume that one's physical conditions are a reflection of one's spiritual choices, then your first move when someone says "I'm in pain, please help me with my pain" is to ask "What have you done to deserve this pain? I won't remove God-given pain; if you deserve it, it would be a sin to do so", instead of "Here's something to make the pain manageable while we figure out how to remove the source of the pain".
I loathe the prosperity gospel too, and never miss a chance to blame its preachers where I can. But in this case I think glorification of suffering can’t be blamed on them because suffering was also fetishized by mother Teresa.
It does seem to be a uniquely American problem though.
Scratchy robes for monks in certain orders has long been a thing all over the world. But successfully banning comfortable clothing for all, regardless of religiosity, is really more of an American thing.
And that of course goes back to the Puritans around at America's founding, who were deeply opposed to anybody having fun or enjoying themselves: https://en.wikipedia.org/wiki/Puritans#Behavioral_regulation...
I also recall reading of Calvinists who came to American in the mid-1800s to be free of such things as vaccines and insurance, because they thought those things interfered with God's plan. A plan, apparently, wherein a lot of people suffered while others stood around and quietly gloated that they were god's favorites.
Is that due to religiousness too?
Where on Earth did you get this idea?
I'm not saying it's wrong, I'm just it's lower than the US, yet less religious, which pretty much blows up OP's thesis.
The exception seems to be fentanyl, which gets handed out to old ladies with dodgy hips who chug it like milk.
And yet benzodiazepines are taken by vast amounts of people as if it was water.
My wife had some core muscles in her back collapse. Think unable to walk and could only crawl with me holding her hips up. When she went to the primary doc, he thought it was drug seeking behavior. When she went to the ER they luckily decided that she was serious and gave her the most powerful muscle relaxant available - Valium. She had no idea, but it it saved her life.
It was extremely scary to go through.
The best muscle relaxant / antispasmodic depends on the patient and the situation. Valium is a safe indication from someone not dealing with those medications, as a temporary measure.
All benzodiazepines (including valium - diazepam) create dependence.
I understand that addiction is a big problem, but this was a male doctor looking at a whole in my testicles, and telling me he can't give me painkillers
>Most people consume ecstasy by mouth, but I’ve heard from many that anal ecstasy is a more satisfying experience.
I think the author was being a little facetious.
It's not, but it should be.
I'm curious if it even absorbs well via the sinuses. From experience with powdered caffeine (mixing with shampoo as a folk treatment for hair loss), it doesn't readily dissolve at room temperature water, though of course it dissolves just fine in hot water, which is why the standard quick extraction from coffee beans involves hot water (cold brew by contrast, involves long periods of steeping for a result that still has less caffeine)
Chemists have wonderful words to quantify the exact degree of solubility under various conditions: "sparingly soluble" means it generally takes 30-100ml of solvent to dissolve 1g of the material in question.
So, if you're hip to the quantity of caffeine in your beans (by, perhaps, grinding and boiling 100g and then analytically extracting the mass of relatively pure caffeine with something like DCM, followed by recrystallization in water maybe), you can figure out how much caffeine will be present in your cold brew based on the quantity of solvent.
IM and subQ is surprisingly not much trouble, as long as you have a relatively pure dissolvable compound and safe solvent (various oils or bacteriostatic water) it takes like 2 minutes and $1.50 in supplies (a $0.25 syringe, two $0.25 needles, and a $1 PVDF/PETF 0.22um syringe filter). Not much more hassle than at-home insulin or TRT injections.
But definitely a huge stigma, and often the pharmacokinetics of IM/subQ administration aren't desirable for many drugs.
Administration is just how you can figure it out for yourself at similar doses.
Go ahead and consume a gram or two of caffeine by any means and compare the stress on the heart and other organs, as well as personality.
Just because it's cheap, legal, and easily available doesn't mean it's safer by comparison.
Also since cocaine users generally consume recreational overdoses doesn't make either one any safer at any dose.
Plus think how many more addicts there are even at much less harmful doses.
Why do you think some of these hard-core caffeine addicts are injecting it anyway, plus handling it as well as they do. Definitely not recommended for anyone who hasn't already built up the tolerance addicts are known for.
Clean living pays off.
To go even more extreme, imagine if there were a nuclear war because somebody who was a little overly nervous pushed "the button".
What drug do you think would be detected if put to the test?
But the story in OP is that the patient received caffeine IV at the beginning of the surgery (inducing severe anxiety).
Does anyone know why you would do this?
When I woke up from the surgery, it was pretty weird. I was wide awake and alert very quickly. Never got a caffeine withdraw headache. It was awesome.
My wife, who had gone through significant discomfort in order to cut off caffeine while pregnant (she was told otherwise the baby could be born already addicted to caffeine), was a bit exasperated when told that almost the first thing they did was give her daughter a caffeine IV. It was probably still the right thing for her to have done (so the caffeine IV had full affect), but I could sympathize with her position.
https://goaskalice.columbia.edu/answered-questions/plugging-...
The question is whether coffee is acidic enough to do damage even without the sugar.
People often drink coffee slowly and without a straw, this leads to staining but not tooth decay. However the slow part contributes to the teeth not getting a chance to neutralize acidity normally. This gets worse when people then brush their teeth after their morning coffee to prevent bad breath, which the abrasiveness combined with the acid environment does cause havok.
Both of them can be avoided in a variety of ways, to reduce both staining and decay.
Tooth decay requires several parameters 1- bacteria 2- bacteria food source 3- acidic environment 4- time
We all have the bacteria but the other ones are somewhat controllable. What many people don’t account for is the 4th parameter of contact time. It would be better (for your teeth, not overall health) to rapidly drink several sodas than periodically sip one for several hours.
Decay typically only occurs in a pH environment of 5.5 or lower, otherwise the enamel is resistant to the acid. So the longer the pH is lower the more likely you will develop a cavity.
Also: it has definitely stained my teeth. Is there a way to remove the stains that doesn't weaken the enamel?
Despite brushing twice a day and now only eating foods with some sugar, dentist agreed had better teeth on the meat and water diet.
That's if I'm reading this correctly and you're describing the smell in your blood?
Not related to caffeine pills though, I get it from caffeine itself.
Nicotine at least is probably more commonly consumed via alternative means now (in North America, in <40 demographics at the very least)
Vaping would likely be the most common, but there are also patches, gum, lozenges, dip, and snuff. I've never heard of anally consumed nicotine though
Never heard of blowing smoke up someone's ass? It was literal in the 18th century.
> ...it was a general mainstream medical procedure used to, among many other things, resuscitate people who were otherwise presumed dead. In fact, it was such a commonly used resuscitation method for drowning victims particularly... Smoke was blown up the rectum by inserting a tube. This tube was connected to a fumigator and a bellows which when compressed forced smoke into the rectum. Sometimes a more direct route to the lungs was taken by forcing the smoke into the nose and mouth, but most physicians felt the rectal method was more effective. The nicotine in the tobacco was thought to stimulate the heart to beat stronger and faster, thus encouraging respiration... Artificial respiration was used if the tobacco enema did not successfully revive them. [1]
So it's not like it was for fun. But I can see how for fast delivery of nicotine, it made perfect sense.
[1] https://gizmodo.com/blowing-smoke-up-your-ass-used-to-be-lit...
If you stretch out your hand and fingers and draw a line down from your index and thumb there’s the radial fossa aka “anatomical snuffbox.”
I’ve never done rectal or IV nicotine but I’ve done all the rest. For my money, the Swedes make the best smokeless tobacco. I’m guessing it’s big there?
"Effects of caffeine administration on sedation and respiratory parameters in patients recovering from anesthesia"
> Caffeine has been shown to enhance the speed of recovery from general anesthesia in murine models, though data in human patients is lacking. This is a retrospective review of intravenous caffeine administration (median dose 150 [125, 250] mg) to 151 heavily sedated patients in the post-anesthesia recovery area, to determine the association between caffeine administration and changes in sedation score, respiratory rate, and oxyhemoglobin saturation.
By the time you release you've had too much, you're not even halfway there.
What a treat.
Ask HN: aside from caffeine, what is the drug of choice around here?
Had some funny experiments in there but would never go back to nothing. It doesn't make sense, especially if you don't have an addictive personality & any chemical risk is more likely associated with quitting beneficial chemicals than staying on them too long.
What's the equivalent of a 300mg IV dose in oral ingestion?
Tangential details...
The 2018 hemp farm bill allows products to have up to 0.3% THC, but it took years for people to realize that gummies are hefty enough that 0.3% means a gummy can have 10-20mg of THC. So, at the ripe age of 57 I finally tried THC.
It was very frustrating because most of the good stuff I expected didn't happen: no euphoria, no munchies, no relaxation. I do get some of the negative things, like dry mouth. The one good thing I get is music enhancement, but only if I do it once a week or less (10-15mg). I've tried doing it more frequently and upping the dose to compensate, but nope: if I invoke the genie too frequently he refuses to come out of the bottle.
Food is totally unchanged for you? Wild! What about movies/tv?
Although I gone up to 25mg while I was experimenting to find a dose that works best for me, my target is 10mg. Maybe that isn't enough to trigger munchies.
Because the only thing I find it good for is music enhancement, I like to take a gummy around 9pm-10pm, then two hours later put on three albums with a particular kind of music, then hope that I get enhancement. If I'm feeling tired that day, though, I put it off because sucks to hit the sweet spot and then immediately fall asleep and not get to enjoy the music.
By enhancement, I mean I experience pronounced stereo separation and deeper notes seem to be very resonant. Sometimes I get little floaty and feel like I'm suspended in zero gravity while I drift to the music. Because I do it only once a week, I don't notice any disruption of my sleep.
EDIT: you asked about TV/movies. I don't watch them, so I don't know.
Thankfully it’s doesn’t cause any serious harm to you as far as drugs go.
I wonder though, about a 100 years ago, when weed was criminalised, it wasn’t just made illegal - people went out of their way to destroy and get rid of every single hemp plant they could find in nature. Across the whole globe no less. That’s quite a statement. Maybe that’s bound to happen again.
I did finally try a real joint -- of course it hits much faster, but the lung irritation and health concerns weren't worth it.
I'm a bit jealous of people who have a great time. A guy in the band I'm in is 45 and has been a daily smoker for 30 years. He is highly functioning -- has a good job, has kids -- and can work while high. I guess he knows exactly his response and does enough to feel good but not enough to cause problems. He also has a really high tolerance.
I'm kind of jealous of your friend. I've been a daily smoker before, and I'm usually able to like do simple tasks and such. But I just get too lazy and dysfunctional. And I feel dumber. Part of me is drawn to that because it's so much easier to be dumb. But I also depend on working memory to make a living and also for my favourite hobbies. Eventually I learned that the only thing that actually works is occasional use. I can't be completely abstinent because then I never actually learn moderation, and I just end up binging again. But if I know I can enjoy myself if I want to, I don't have to be constantly thinking "fuck I want some weed". And then when I do finally give in, there's this shame spiral about it that leads to binging. Whereas now I can just smoke if I feel like it, have a great night of sleep and go on with my life the next day.
Watching my brother destroy his life with Heroin has kept me away from opioids for the most part, but I don't like the way they make me feel anyway.
Wow writing that all out makes me look like a degenerate :)
Wellbutrin (NDRI) every morning. Helps with attention and alertness. It isn't classified as a stimulant, so I don't need to deal with the regulations around regular ADHD meds. It also helps with sexual dysfunction caused by other meds.
Benzos for social events. Way better than alcohol. All of the chill and none of the impairment. :)
Don't come at me: I'm not recommending this, I've never done it, and your nurse friends probably won't do it for you.
Edit: TIL it's not illegal. However, in a hospital I'm pretty sure the nurses aren't supposed to do it for free.
The illegal part is if the nurse is stealing the IV and “works” from their workplace (a hospital).
Being at a high altitude, hangovers suck up here, so there may be a market. I don't drink anymore - and it wasn't a hard decision. I haven't been down to sea level in a very long time, but drinking is completely different up here than down there.
[1]: https://www.elle.com/beauty/health-fitness/advice/a14177/iv-...