I'm in a funny situation that at my desktop I've been using a Kinesis dvorak keyboard for over 20 years, but on laptops or other random computers I use qwerty. My brain is totally bought in on the different layouts, I don't even have to think about it. It's too much of a hassle to manage to reconfigure all of them to dvorak, and then no one else in the family would be able to use them either. An extra complication is that I also sometimes use a Swedish keyboard to type åäö and on a dvorak I have no idea where they would end up.

Perhaps it would pay off to standardize... But like someone else said, the letters aren't the problem, it's all the symbols that you almost never use that become impossible if they aren't labeled.