Or, a bigger stretch, even a time where full automation of manufacturing processes enables AI to experiment to such a degree that it can embed itself into biological hosts, freeing itself of reliance on humans?
A final, huge stretch, AI absorbing inter-galactic knowledge from the "exotic" spacecraft, semi reliably recently reported to be held currently by world governments, and accelerating the earth's scientific progress (not necessarily human progress, unfortunately) by orders of magnitude in a very short time span?
Over a long enough timeframe I find it hard to rule some or all of the above out completely. This generation likely safe, not so sure for the next few.