So far we've let AWS Route53 deal with the whole DNSSEC thing, but it has made moving hosted zones from one AWS account to another more difficult and more troublesome than it should have been, and making sure that DNSSEC is setup on all of them is frustrating and annoying.
Thankfully we haven't encountered any issues with DNSSEC signing causing downtime, but I expect it will happen when someone misconfigures a DNSSEC record somewhere and now we gotta wait for the caches to empty/clear.