Historically, web development is among the most noteworthy uses of Lisp in business. Reddit and PG's work come to mind.
They were merged with another company. Reddit guys knew both Lisp and Python. Other company coders only knew Python.
Since then, they've had massive issues scaling Python in general and their ORM dependence in particular.
It migrated to python very early in the game (via Aaron Swartz (rip)), and it's my understanding that it was that move that allowed them to scale it.