I host my packages on my own server using the PEP 503 "Simple Repository API". (For what it's worth, Donald Stufft, author of this PyPI blog post, also wrote PEP 503.)
I migrated away from PyPI years ago because modern FOSS distribution is increasingly intermediated by package managers, which I think worsens the connection between user and producer by adding a layer of anonymity.
I see 2FA as a technical work-around using mechanical trust instead of personal trust.
I don't care if people who don't know about me or my project web site can't find it on PyPI, because care is reciprocal - I want them to care about me too, at least enough to know where the project came from. That's where I think trust comes from.
My packages will never be popular. I develop very specialized software for a field with perhaps 10,000 world-wide users. No one will pay for my software, or hire my services, if they only visit PyPI.
I thankfully still have a Python 2.7 version of my software on PyPI. I haven't deleted it, to make name-squatting harder. It's even lead people to contact me directly, to ask about Python 3 support. I never would have heard from them, had I published the newest versions on PyPI, and that direct contact breaks the anonymity PyPI interposes.
A nice plus is how hosting means I have full access to the download logs, giving me insight onto what platforms people use that PyPI doesn't provide, because "anonymity".
The biggest annoyance is they main reason I started using PyPI was because someone else added another project of mine to PyPI.
I distributed https://pypi.org/project/PyRSS2Gen/ on my own web site as source. Someone else added it to PyPI, with me listed as the primary developer. I didn't know about it until the PyPI devs emailed developers like me to encourage them to support Python 3! I then had to ask that stranger for access to the PyPI entry.
I fear that will happen again, if I ever develop a new package that I distribute myself.
I hope this provide something for you to chew on, as you consider what you might do.