Sony got into big trouble with the Playstation 3 because it was an exotic machine and hard to program so they created the PhyreEngine which was a cross-platform toolkit that made it practical to target many competitive platforms

https://en.wikipedia.org/wiki/PhyreEngine

which ironically was based on Microsoft’s .NET. It was capable of making AAA games but also accessible to independent devs. Many games are based on other platforms like Unreal that make many aspects of the game portable. Of course games have graphics, sound and real-time requirements that most applications don’t have.

If your just trying to get functionality out and the UI isn't a big part of the value proposition then why not.