I guess, now is the ideal time for me to experiment with LXD or Docker images that are based on Alpine Linux or Debian Slim for QUIC support for Nginx.
Footnote: I actually love musl, just for my own software that explicitly targets it and is validated against it.
Most software isn't written with Musl in mind! And that shows.
You can run in all kinds of extremely hard to debug issues and especially massive performance problems. Stuff may slow down to fractions of the performance comparison to regular Linux distros.
If you want maximal small containers go with Distroless.