It doesn't seem to work for me. I am on a network where all web proxies are blocked. I tried accessing anonymouse.org and I got the default page which is used to inform blocked domains on my network. I can ping to the ip of anonymouse.org. I tested whether I have setup dnscrypt correctly with: "sudo tcpdump udp port dns" it showed very long unreadable lines which I have not seen before using dnscrypt. For anonymouse.org this was the tcp dump output:

12:57:43.523694 IP mypc-ubuntu.local.38481 > resolver2.opendns.com.domain: 28982 updateM [b2&3=0x666e] [27192a] [30295q] [20660n] [52086au][|domain]

12:57:43.801981 IP resolver2.opendns.com.domain > mypc-ubuntu.local.38481: 29238 updateM [b2&3=0x666e] [27192a] [30295q] [414n] [12287au] Type65535 (Class 13704)? [|domain]

There should have been a third line with the encrypted lines, but it doean't show up for anonymouse.org. Where as the third line with encrypted payload gets shown to the domains that are whitelisted in my network.