My favorite fat loss drug along these lines is dinitrophenol. It is the true miracle fat burning drug. It interferes with cellular metabolism in such a way that the body just nonstop oxidizes fat. Fat mass loss in the order of a pound a day or more is entirely possible and some bodybuilders use it to get to a ludicrously low bodyfat percentage. Unfortunately oxidizing that much fat generates a lot of heat, so much that an overdose can be lethal because your body literally roasts itself to death and titration is extremely difficult. Oh and blindness is a common side effect. And for added fun it’s an high explosive. Needless to say it’s not FDA approved.