Not lifting, but you can push the machine horizontally from your normal position with your hands on the buttons. With your hands at the front corners, you can push north-south or east-west or on any such axis. The machines are designed to allow this; the legs and feet have some flex.
What's different from people's experience of virtual pinball is that you're moving the machine underneath the ball, not the ball itself. The computer games like Space Cadet let you deflect the ball in open space anywhere on the playfield... that's not really how it works, Microsoft got that wrong, what you're really doing is pushing objects on the playfield either into or away from the ball.