The pushback is usually along the lines of "the programmer of the simulation isn't a supernatural being like a god" but if indeed this is a simulation (I don't buy that it is) then the programmer(s) of that simulation have supernatural abilities from the perspective of those of us observing from inside the simulation.
I think there's a substantial difference between saying God has a plan for us and saying that our universe was likely manufactured in another for some unknown reason. Also, and I may be mistaken here, I think Creationists generally believe that the plane in which God exists is the top level (and therefore God must be a significant entity), while simulationists think it's only marginally more likely that our parent universe is not a simulation.
Either way it would be saying that the universe we perceive was created by an intelligent agent as opposed to by naturalistic forces. Doesn't seem to matter whether that intelligent agent had a specific plan in mind for humans or not - sure, some creationists might stress that there's a positive plan for humans specifically, but I'm not sure all creationists would say this. [There are a lot of different types of creationists - 6day creationists, intelligent designer creationists, evolutionary creationists, deists, etc. - the common denominator is that an intelligent agent initially got the universe going ]
> while simulationists think it's only marginally more likely that our parent universe is not a simulation.
so simulations all the way down?
Might be a builtin fault in the human brain?
The average human looks around in wonder at the world, and thinks "someone or something created it!"[1]. Whether they think that the creator matches their definition of a god or their definition of an engineer is an unimportant detail.
[1] As an atheist, I used to be routinely presented with this argument, viz "Look at the irreducible complexity in the human eye/human brain/$whatever. Can you truly say that such complexity was arrived at by randomness?". Sometimes, I'd even agree with the argument that the argument that the existence of complexity is evidence of a creator of that complexity. Then I'd point out that this creator itself is complex, and hence had to have, itself, a creator...