The major difference was that several of the steps went in parallel instead of sequence because there was the money, people, and will to do it.
That not true.
Important steps were skipped or shortened.
For example, blinding was broken a relatively short time after the beginning of the trial. Participant were notified whether they were part of the trial group or placebo group.
This makes the trial useless for the possibility of long term side effects.
I assumed this was well known.
https://www.npr.org/sections/health-shots/2021/02/19/9691430...
Edit: note that the NPR piece missed the more important problem. While some people in the placebo group decided to continue the study and not to take the vaccine, blinding was irrecoverably broken, and what is worse, they are self selected, so randomization is gone as well.
Not giving these people the shots would have been immoral, it was already clear that they were effective and safe.
It was not clear that they were long-term safe; there was not enough long-term data yet to discover this. And by unblinding, they made it very hard to gather such data.
Now that we have some such data, we see that indeed there are some non-trivial long term risks, such as doubling the risk of blood clotting in the eyes: https://www.nature.com/articles/s41541-023-00661-7 .
Doubling a miniscule risk. Even if true, this is orders of magnitude less consequential than the benefit gained by giving people the vaccine, instead of maintaining the blind group.
Yes, important steps were skipped or shortened for the unprecedented approval of these vaccines.
> Not giving these people the shots would have been immoral, it was already clear that they were effective and safe.
How can it be clear that they were safe if you haven't done any type of longer term followup?
If true, this link doesn't say it.
That is, they stopped blinding half a year before the vaccine was actually approved.
mrna vaccines are a promising technology but LNPs being modeled after viral membranes do pose general dangers to the body as the full evolutionary dance of their development is something we may never know. seeing as membranes are, naturally, older than the receptors that have extended their functions, any contributions to 'tricking' host immune systems may have nasty effects at larger scales than would normally be given by natural infection. how they affect various molecular pathways can pose a multitudes of threats.
there have already been widespread discussions on this topic and many others by appropriate experts in a wide variety of professions, you can find some here:
https://lakaruppropet.se/international-conference-pandemic-s...
https://noagendaassets.com/enc/1684100123.718_supercutunvaxx...