Isaacson was the perfect writer for this biography, in my opinion, thanks to his lack of technical knowledge. When you know the technology, it's easy to get lost in the things that don't matter. Isaacson has a fresh and often more objective perspective than any tech writer could. The details surrounding which kernel was used in Mac OS X and how much NeXT was responsible for really does not bring much value to me as a reader. Like I said, if I cared deeply about this, it's well documented already and easy to get from other sources.
What I got out of the book was a remarkably intimate look at the man himself: What made him tick, what his philosophies were, what the politics were and what the major obstacles were that he had to overcome. All of this, wrapped in an enthralling narrative and surprisingly intimate detail.
Isaacson may not have understood the technology, but he definitely understood Jobs' humanity, or sometimes lack thereof.