I know some of the HN crowd are gonna wag their finger at me but the moment I have to deal with timestamps in Python, even for the most simplest of cases, I parachute in pandas. `pd.Timestamp` (and its friends like `pd.Timedelta`) in my opinion are the most powerful timestamp toolkit available anywhere.
To me it's very often easily worth the extra 50-150MB of install size that just works. I've used pandas for around 7 years now and it was inconsistent and buggy at the beginning. But these days, it's practically flawless. Also I'm aware that pd.Timestamp is built on top of many awesome libraries.