For instance, if we label the undesirable outputs as BAD, then we can write a formula like G!BAD (read: always not BAD), and ask if there exists a program which models this formula - if there does, then we know there's some program which never enters the undesirable states, regardless of the input. You can extend this from a decision problem (yes/no answers) to synthesis, and construct such a program using similar techniques (I'm using "program" in a very specific sense here - much of the current art is focused around finite-state automata).
Shameless plug: I wrote my thesis on decision problems around the existence of game-theoretic solutions concepts (e.g. Nash equilibria, the Core) in multi-agent systems and many of these were 2EXPTIME-complete. A lot of the time you could easily show membership in 2EXPTIME by making an exponential(!) number of relevant calls to the LTL realizability problem.