It's worth elaborating this one, because testing whether an ordinary star-free regular expression has no matches is super easy. Not sure what the author means by "CS" (maybe just "computer science"?), but the actual problem is "Does a generalized regular expression without stars have no matches?" Here, "generalized" means that we have two new operators, beyond union (alternation) and concatenation: they are intersection and negation. [0]
You may recall that constructing an intersection automaton involves a cross product of NFAs, and constructing the negation automaton involves just flipping the accepting/rejecting states of a DFA. However, the NFA -> DFA construction can incur an exponential blowup of states.
So at the very least, intuition shows that the automata we're working with are enormous w.r.t. the expression size. But at this point my intuition stops, so I won't be able to explain how we get from here to a TOWER-complete decision procedure for whether the accepting set is empty.