When you talk to folks in politics around the periphery of Congress and the white house and you bring up major systemic change, in my experience they shake their head and say, "let me stop you there."
There is only 1 issue they care about. They all say it is the root, the basis for any and all other change.
Campaign finance reform. When you are campaigning and fundraising full time you cannot and will not do your job as a legislator. I have heard this over and over and over.
"What if we..." Campaign finance reform. "But isn't..." Campaign finance reform. "How about..." Campaign finance reform.