I doubt that the Mojo developers have some sort of 'secret sauce' or 'special trick' that will get them there. And even if they have something, I don't see why the Python devs wouldn't just implement the same approach, considering they're currently trying to make Python faster.
I assume that (as long as Mojo wants to stick to its goal of being a strict superset of Python), there will be a lot of things that just cannot be 'fixed'. For example, I'd be surprised if Python's Global Interpreter Lock isn't entangled with the language in a few nasty ways that'd make it really difficult to replace or improve upon (while retaining compatibility).
Then again, the developer of Swift is working on it, right? I guess he's got the experience, at least.