It's clear she struggled with depression and some sort of compulsion to live in public in a painful, raw way, pretty much all her adult life. Like many people in her circumstances, she had a love-hate relationship with an audience that often abused her, but was also the source of her income. It's also clear that all of this took a turn for the worse recently. Less than a year ago she posted this rambling, semi-coherent rant that has since been scrubbed from her blog:
https://web.archive.org/web/20220811035913/https://dooce.com...
In it, she speaks about her history of mental illness, body dysphoria and attempted suicide. She also says some things about gender dysphoria: she objects to the fact that affirmation is the only treatment offered, is scornful of neo-pronouns, hints that she feels her non-binary children have been swept up in a social contagion, and praises the bravery of de-transitioners. Needless to say, people did not take this kindly, as the comments on her Instagram around this time shoes:
https://www.instagram.com/p/ChGWRv-JN2m/
She was subjected to an enormous torrent of self-righteous abuse by her fanbase in the wake of this. Podcasts were made, Reddit threads savaged her, Twitter did its sociopathic thing, and it dragged on for weeks and weeks.
I'm not saying her fanbase bullied her to death. But I am saying that the way she was treated surely didn't help.