The webassembly-language-runtimes is focused on providing WASI-based language interpreters, what would require a WASI polyfill at the browser level (https://wasi.dev/polyfill/) and (https://github.com/bjorn3/browser_wasi_shim).

Pyodide is certainly another option, but is emscripten based, not based in webassembly-language-runtimes or WASI.