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The anti-aging effects of rapamycin support the opposite of "pervasive accumulation of entropy" theory - which is that aging is a distorted development program, rather than random accumulation of entropy.

The definition of "random" implies by default that lack of information or knowledge on the object in question is primarily due to cognitive (and hence measurement) limitations of its users, rather than something being 100% objectively ingrained in reality.

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Only chink in that theory is rapamycin doesn't seem to have anti-aging effects per-se, rather a wide array of systemic effects, some beneficial to longevity in special circumstances. In the general case, you definitely won't be extending lifespan of the elderly by modulating down their immune system or promoting amyloid formations.

There is definitely "real" randomness, DNA replication errors are truly random because they are caused by quantum molecular effects. You can characterize them statistically and reduce their incidence, for example by controlling the diet or shielding the body from UV, but you can't measure those causes, only observe their effects. At best you could correct them, starting from a known-good-copy, as indeed cell biology already does.

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